The Dutch international was thought to be eager to show loyalty to the club after they helped him through his last knee injury, however, negotiations have proved to be difficult so far.
Reports suggest that a low release-clause and agency fees are the main issues between getting a new contract settled for De Vrij.
The 26-year-old is set to be out of contract in the summer and it’s believed the likes of Premier League giants Manchester United, Chelsea and Liverpool are all monitoring the defender’s situation in the Italian capital.
Uwe Rosler was sacked by Fleetwood following a 3-0 reverse at Doncaster which condemned Town to a seventh straight defeat in all competitions.
Cambridge interim head coach Joe Dunne was pleased with how his side adapted to beat Grimsby 3-1.