Brighton moved a point further clear of the relegation zone after holding Wolves to a 0-0 draw at Molineux.
Chelsea's European journey appears to be at an end after a comprehensive 3-0 home defeat in the last 16 against Bayern Munich.
Anthony Martial's first-half leveller ensured Manchester United avoided a Europa League last-32 defeat at Club Brugge.
Fraser Forster saved a late penalty as Celtic almost grabbed defeat from the jaws of victory in Denmark.
Manchester United made it three wins over Chelsea this season via goals from Anthony Martial and Harry Maguire at Stamford Bridge.
An own goal from Adrian Mariappa denied Watford a crucial three points after taking the lead at Brighton.
Slaven Bilic enjoyed his West Ham return as Championship leaders West Brom dumped the Hammers out of the FA Cup.
Substitute Sofiane Boufal ensured Southampton deservedly got a second chance at Tottenham in the FA Cup fourth round.
They needed extra-time to do it but Tranmere saw off Premier League Watford to set up a clash with Manchester United.
Roberto Firmino was Liverpool's match-winner late on at Molineux against a spirited Wolves side.